5WP0

Crystal structure of NAD synthetase NadE from Vibrio fischeri

Summary for 5WP0

• Entry DOI: 10.2210/pdb5wp0/pdb
• Descriptor: NH(3)-dependent NAD(+) synthetase (2 entities in total)
• Functional Keywords: structural genomics, niaid, national institute of allergy and infectious diseases, alpha beta, 3-layer(aba) sandwich, rossmann fold, nad synthetase, ligase, center for structural genomics of infectious diseases, csgid
• Biological source: Vibrio fischeri (strain ATCC 700601 / ES114)
• Total number of polymer chains: 2
• Total formula weight: 61439.78

Authors

Stogios, P.J.,Evdokimova, E.,Grimshaw, S.,Savchenko, A.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2017-08-03, release date: 2017-08-16, Last modification date: 2025-06-18)

Primary citation

Inniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F.
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.
Microbiol Resour Announc, :e0020025-e0020025, 2025

PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.

PubMed: 40391899
DOI: 10.1128/mra.00200-25

Experimental method

X-RAY DIFFRACTION (2.6 Å)