5WO9

Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6* in the presence of Calcium

5WO9 の概要

• エントリーDOI: 10.2210/pdb5wo9/pdb
• 分子名称: Transient receptor potential cation channel subfamily V member 6, 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION (3 entities in total)
• 機能のキーワード: ion channel, transporter, membrane protein
• 由来する生物種: Rattus norvegicus (Rat)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 77467.99

構造登録者

Singh, A.K.,Saotome, K.,Sobolevsky, A.I. (登録日: 2017-08-01, 公開日: 2017-09-13, 最終更新日: 2024-12-25)

主引用文献

Singh, A.K.,Saotome, K.,Sobolevsky, A.I.
Swapping of transmembrane domains in the epithelial calcium channel TRPV6.
Sci Rep, 7:10669-10669, 2017

PubMed Abstract: Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.

PubMed: 28878326
DOI: 10.1038/s41598-017-10993-9

実験手法

X-RAY DIFFRACTION (3.7 Å)