5WO7
Crystal Structure of Transient Receptor Potential (TRP) channel TRPV6*
Summary for 5WO7
| Entry DOI | 10.2210/pdb5wo7/pdb |
| Descriptor | Transient receptor potential cation channel subfamily V member 6, 6-(5-METHYL-2-OXO-IMIDAZOLIDIN-4-YL)-HEXANOIC ACID, CALCIUM ION (3 entities in total) |
| Functional Keywords | ion channel, transporter, membrane protein |
| Biological source | Rattus norvegicus (Rat) |
| Total number of polymer chains | 1 |
| Total formula weight | 77854.43 |
| Authors | Singh, A.K.,Saotome, K.,Sobolevsky, A.I. (deposition date: 2017-08-01, release date: 2017-09-13, Last modification date: 2023-10-04) |
| Primary citation | Singh, A.K.,Saotome, K.,Sobolevsky, A.I. Swapping of transmembrane domains in the epithelial calcium channel TRPV6. Sci Rep, 7:10669-10669, 2017 Cited by PubMed Abstract: Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states. PubMed: 28878326DOI: 10.1038/s41598-017-10993-9 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.246 Å) |
Structure validation
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