5WLT

Carbonic Anhydrase IX-mimic in complex with aryloxy-2-hydroxypropylammine sulfonamide

5WLT の概要

• エントリーDOI: 10.2210/pdb5wlt/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, 4-{(2S)-2-hydroxy-3-[(propan-2-yl)amino]propoxy}benzene-1-sulfonamide, ... (5 entities in total)
• 機能のキーワード: carbonic anhydrase, beta adrenergic receptor, sulfonamide, aryloxy-2-hydroxypropylammine, lyase, lyase-inhibitor complex, lyase/inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 30243.60

構造登録者

Lomelino, C.L.,Andring, J.T.,McKenna, R. (登録日: 2017-07-27, 公開日: 2018-08-01, 最終更新日: 2023-10-04)

• 主引用文献: Nocentini, A.,Ceruso, M.,Bua, S.,Lomelino, C.L.,Andring, J.T.,McKenna, R.,Lanzi, C.,Sgambellone, S.,Pecori, R.,Matucci, R.,Filippi, L.,Gratteri, P.,Carta, F.,Masini, E.,Selleri, S.,Supuran, C.T.; Discovery of beta-Adrenergic Receptors Blocker-Carbonic Anhydrase Inhibitor Hybrids for Multitargeted Antiglaucoma Therapy.; J. Med. Chem., 61:5380-5394, 2018; PubMed: 29851481; DOI: 10.1021/acs.jmedchem.8b00625

実験手法

X-RAY DIFFRACTION (1.57 Å)