5WJJ

Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors

5WJJ の概要

• エントリーDOI: 10.2210/pdb5wjj/pdb
• 分子名称: Mitogen-activated protein kinase 14, N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methyl-1-oxo-1lambda~5~-pyridine-4-carboxamide (3 entities in total)
• 機能のキーワード: transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : Q16539
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42168.98

構造登録者

Snell, G.P.,Okada, K.,Bragstad, K.,Sang, B.-C. (登録日: 2017-07-23, 公開日: 2018-01-17, 最終更新日: 2024-03-13)

• 主引用文献: Kaieda, A.,Takahashi, M.,Takai, T.,Goto, M.,Miyazaki, T.,Hori, Y.,Unno, S.,Kawamoto, T.,Tanaka, T.,Itono, S.,Takagi, T.,Hamada, T.,Shirasaki, M.,Okada, K.,Snell, G.,Bragstad, K.,Sang, B.C.,Uchikawa, O.,Miwatashi, S.; Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors.; Bioorg. Med. Chem., 26:647-660, 2018; PubMed: 29291937; DOI: 10.1016/j.bmc.2017.12.031

実験手法

X-RAY DIFFRACTION (1.6 Å)