5WFQ
Ligand-bound Ras:SOS:Ras complex
Summary for 5WFQ
Entry DOI | 10.2210/pdb5wfq/pdb |
Descriptor | GTPase HRas, Son of sevenless homolog 1, MAGNESIUM ION, ... (6 entities in total) |
Functional Keywords | ras, sos, oncoprotein, protein-protein interaction, mapk, signaling protein |
Biological source | Homo sapiens (Human) More |
Cellular location | Cell membrane. Isoform 2: Nucleus: P01112 |
Total number of polymer chains | 3 |
Total formula weight | 95362.01 |
Authors | Sun, Q.,Phan, J.,Burns, M.C.,Fesik, S.W. (deposition date: 2017-07-12, release date: 2018-05-23, Last modification date: 2023-10-04) |
Primary citation | Burns, M.C.,Howes, J.E.,Sun, Q.,Little, A.J.,Camper, D.V.,Abbott, J.R.,Phan, J.,Lee, T.,Waterson, A.G.,Rossanese, O.W.,Fesik, S.W. High-throughput screening identifies small molecules that bind to the RAS:SOS:RAS complex and perturb RAS signaling. Anal. Biochem., 548:44-52, 2018 Cited by PubMed: 29444450DOI: 10.1016/j.ab.2018.01.025 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.26 Å) |
Structure validation
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