5WFL
Kelch domain of human Keap1 in open unliganded conformation
Summary for 5WFL
Entry DOI | 10.2210/pdb5wfl/pdb |
Descriptor | Kelch-like ECH-associated protein 1, SULFATE ION (3 entities in total) |
Functional Keywords | scaffold, unliganded, transcription |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 74278.67 |
Authors | Carolan, J.P.,Lynch, A.J.,Allen, K.N. (deposition date: 2017-07-12, release date: 2018-09-19, Last modification date: 2023-10-04) |
Primary citation | Zhong, M.,Lynch, A.,Muellers, S.N.,Jehle, S.,Luo, L.,Hall, D.R.,Iwase, R.,Carolan, J.P.,Egbert, M.,Wakefield, A.,Streu, K.,Harvey, C.M.,Ortet, P.C.,Kozakov, D.,Vajda, S.,Allen, K.N.,Whitty, A. Interaction Energetics and Druggability of the Protein-Protein Interaction between Kelch-like ECH-Associated Protein 1 (KEAP1) and Nuclear Factor Erythroid 2 Like 2 (Nrf2). Biochemistry, 59:563-581, 2020 Cited by PubMed: 31851823DOI: 10.1021/acs.biochem.9b00943 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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