5WFJ

THE JAK3 KINASE DOMAIN IN COMPLEX WITH A COVALENT INHIBITOR

5WFJ の概要

• エントリーDOI: 10.2210/pdb5wfj/pdb
• 分子名称: Tyrosine-protein kinase JAK3, 4-({[3-(propanoylamino)phenyl]methyl}amino)pyrrolo[1,2-b]pyridazine-3-carboxamide (3 entities in total)
• 機能のキーワード: transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Endomembrane system ; Peripheral membrane protein : P52333
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33591.39

構造登録者

Sack, J. (登録日: 2017-07-12, 公開日: 2017-10-04, 最終更新日: 2017-10-11)

• 主引用文献: Kempson, J.,Ovalle, D.,Guo, J.,Wrobleski, S.T.,Lin, S.,Spergel, S.H.,Duan, J.J.,Jiang, B.,Lu, Z.,Das, J.,Yang, B.V.,Hynes, J.,Wu, H.,Tokarski, J.,Sack, J.S.,Khan, J.,Schieven, G.,Blatt, Y.,Chaudhry, C.,Salter-Cid, L.M.,Fura, A.,Barrish, J.C.,Carter, P.H.,Pitts, W.J.; Discovery of highly potent, selective, covalent inhibitors of JAK3.; Bioorg. Med. Chem. Lett., 27:4622-4625, 2017; PubMed: 28927786; DOI: 10.1016/j.bmcl.2017.09.023

実験手法

X-RAY DIFFRACTION (2.48 Å)