5WF6

Agonist bound human A2a adenosine receptor with S91A mutation at 2.90 A resolution

Summary for 5WF6

• Entry DOI: 10.2210/pdb5wf6/pdb
• Descriptor: Human A2a adenosine receptor T4L chimera, 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total)
• Functional Keywords: human a2a adenosine receptor, s91a, gpcr-t4l chimera, membrane protein, lcp, agonist, uk432097, activation microswitch, allosteric na-site mutant, gpcr signaling
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell membrane; Multi-pass membrane protein: P29274
• Total number of polymer chains: 1
• Total formula weight: 57674.47

Authors

White, K.L.,Eddy, M.T.,Gao, Z.,Han, G.W.,Hanson, M.A.,Lian, T.,Deary, A.,Patel, N.,Jacobson, K.A.,Katritch, V.,Stevens, R.C. (deposition date: 2017-07-11, release date: 2018-02-21, Last modification date: 2023-10-04)

• Primary citation: White, K.L.,Eddy, M.T.,Gao, Z.G.,Han, G.W.,Lian, T.,Deary, A.,Patel, N.,Jacobson, K.A.,Katritch, V.,Stevens, R.C.; Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling.; Structure, 26:259-269.e5, 2018; PubMed: 29395784; DOI: 10.1016/j.str.2017.12.013

Experimental method

X-RAY DIFFRACTION (2.9 Å)