5WF6

Agonist bound human A2a adenosine receptor with S91A mutation at 2.90 A resolution

5WF6 の概要

• エントリーDOI: 10.2210/pdb5wf6/pdb
• 分子名称: Human A2a adenosine receptor T4L chimera, 6-(2,2-diphenylethylamino)-9-[(2R,3R,4S,5S)-5-(ethylcarbamoyl)-3,4-dihydroxy-oxolan-2-yl]-N-[2-[(1-pyridin-2-ylpiperidin-4-yl)carbamoylamino]ethyl]purine-2-carboxamide, (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, ... (4 entities in total)
• 機能のキーワード: human a2a adenosine receptor, s91a, gpcr-t4l chimera, membrane protein, lcp, agonist, uk432097, activation microswitch, allosteric na-site mutant, gpcr signaling
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Cell membrane; Multi-pass membrane protein: P29274
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 57674.47

構造登録者

White, K.L.,Eddy, M.T.,Gao, Z.,Han, G.W.,Hanson, M.A.,Lian, T.,Deary, A.,Patel, N.,Jacobson, K.A.,Katritch, V.,Stevens, R.C. (登録日: 2017-07-11, 公開日: 2018-02-21, 最終更新日: 2023-10-04)

• 主引用文献: White, K.L.,Eddy, M.T.,Gao, Z.G.,Han, G.W.,Lian, T.,Deary, A.,Patel, N.,Jacobson, K.A.,Katritch, V.,Stevens, R.C.; Structural Connection between Activation Microswitch and Allosteric Sodium Site in GPCR Signaling.; Structure, 26:259-269.e5, 2018; PubMed: 29395784; DOI: 10.1016/j.str.2017.12.013

実験手法

X-RAY DIFFRACTION (2.9 Å)