5WET

Crystal Structure of H2-Dd with disulfide-linked 6mer peptide

5WET の概要

• エントリーDOI: 10.2210/pdb5wet/pdb
• 分子名称: H-2 class I histocompatibility antigen, D-D alpha chain, Beta-2-microglobulin, Surface protein gp120, ... (5 entities in total)
• 機能のキーワード: antigen presentation, peptide editing, major histompatibility complex class i, mhc-i, tapbpr, h2-dd, h-2dd, tapasin, peptide loading complex, plc, immune response, immune system
• 由来する生物種: Mus musculus (Mouse); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01900; Secreted: P01887; Surface protein gp120: Virion membrane ; Peripheral membrane protein . Transmembrane protein gp41: Virion membrane ; Single-pass type I membrane protein : P03377
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44709.20

構造登録者

Jiang, J.S.,Natarajan, K.,Boyd, L.F.,Margulies, D.H. (登録日: 2017-07-10, 公開日: 2017-10-18, 最終更新日: 2017-12-13)

• 主引用文献: Jiang, J.,Natarajan, K.,Boyd, L.F.,Morozov, G.I.,Mage, M.G.,Margulies, D.H.; Crystal structure of a TAPBPR-MHC I complex reveals the mechanism of peptide editing in antigen presentation.; Science, 358:1064-1068, 2017; PubMed: 29025991; DOI: 10.1126/science.aao5154

実験手法

X-RAY DIFFRACTION (2.64 Å)