5WDF

Crystal structure of 10E8v4-5R+100cF Fab in complex with HIV-1 gp41 peptide

Summary for 5WDF

• Entry DOI: 10.2210/pdb5wdf/pdb
• Descriptor: 10E8v4-5R+100cF Fab heavy chain, FA10E8v4-5R+100cF FAB light chain, HIV-1 gp41 peptide (3 entities in total)
• Functional Keywords: hiv-1 neutralizing antibody, mper, 10e8, immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 100758.42

Authors

Kwon, Y.D.,Kwong, P.D. (deposition date: 2017-07-05, release date: 2018-03-21, Last modification date: 2023-10-04)

• Primary citation: Kwon, Y.D.,Chuang, G.Y.,Zhang, B.,Bailer, R.T.,Doria-Rose, N.A.,Gindin, T.S.,Lin, B.,Louder, M.K.,McKee, K.,O'Dell, S.,Pegu, A.,Schmidt, S.D.,Asokan, M.,Chen, X.,Choe, M.,Georgiev, I.S.,Jin, V.,Pancera, M.,Rawi, R.,Wang, K.,Chaudhuri, R.,Kueltzo, L.A.,Manceva, S.D.,Todd, J.P.,Scorpio, D.G.,Kim, M.,Reinherz, E.L.,Wagh, K.,Korber, B.M.,Connors, M.,Shapiro, L.,Mascola, J.R.,Kwong, P.D.; Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody.; Cell Rep, 22:1798-1809, 2018; PubMed: 29444432; DOI: 10.1016/j.celrep.2018.01.023

Experimental method

X-RAY DIFFRACTION (3.1 Å)