5WD9

Crystal structure of Legionella pneumophila effector lpg2328

5WD9 の概要

• エントリーDOI: 10.2210/pdb5wd9/pdb
• 分子名称: Lem22 (2 entities in total)
• 機能のキーワード: bacterial effector, legionella, protein binding, structural genomics, montreal-kingston bacterial structural genomics initiative, bsgi
• 由来する生物種: Legionella pneumophila subsp. pneumophila ATCC 43290
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 10529.94

構造登録者

Kozlov, G.,Wong, K.,Gehring, K.,Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI) (登録日: 2017-07-04, 公開日: 2017-11-29, 最終更新日: 2024-04-03)

主引用文献

Kozlov, G.,Wong, K.,Gehring, K.
Crystal structure of the Legionella effector Lem22.
Proteins, 86:263-267, 2018

PubMed Abstract: Legionella pneumophila is a pathogen causing severe pneumonia in humans called Legionnaires' disease. Lem22 is a previously uncharacterized effector protein conserved in multiple Legionella strains. Here, we report the crystal structure of Lem22 from the Philadelphia strain, also known as lpg2328, at 1.40 Å resolution. The structure shows an up-and-down three-helical bundle with a significant structural similarity to a number of protein-binding domains involved in apoptosis and membrane trafficking. Sequence conservation identifies a putative functional site on the interface of helices 2 and 3. The structure is an important step toward a functional characterization of Lem22.

PubMed: 29159828
DOI: 10.1002/prot.25427

実験手法

X-RAY DIFFRACTION (1.4 Å)