5WCA

Crystal structure of the broadly neutralizing Influenza A antibody VRC 315 27-1C08 Fab.

Summary for 5WCA

Entry DOI	10.2210/pdb5wca/pdb
Descriptor	VRC315 27-1C08 Fab Heavy chain, VRC315 27-1C08 Fab Light chain (3 entities in total)
Functional Keywords	immune system, antibody, influenza, human vaccine trial
Biological source	Homo sapiens More
Total number of polymer chains	2
Total formula weight	46750.11
Authors	Joyce, M.G.,Andrews, S.F.,Mascola, J.R.,McDermott, A.B.,Kwong, P.D. (deposition date: 2017-06-29, release date: 2017-08-02, Last modification date: 2023-10-04)
Primary citation	Andrews, S.F.,Joyce, M.G.,Chambers, M.J.,Gillespie, R.A.,Kanekiyo, M.,Leung, K.,Yang, E.S.,Tsybovsky, Y.,Wheatley, A.K.,Crank, M.C.,Boyington, J.C.,Prabhakaran, M.S.,Narpala, S.R.,Chen, X.,Bailer, R.T.,Chen, G.,Coates, E.,Kwong, P.D.,Koup, R.A.,Mascola, J.R.,Graham, B.S.,Ledgerwood, J.E.,McDermott, A.B. Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans. Sci Immunol, 2:-, 2017 Cited by PubMed: 28783708 DOI: 10.1126/sciimmunol.aan2676 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.369 Å)

Structure validation