5WAD

ADC-7 in complex with boronic acid transition state inhibitor CR161

5WAD の概要

• エントリーDOI: 10.2210/pdb5wad/pdb
• 分子名称: Beta-lactamase, phosphonooxy-[[[6-(1~{H}-1,2,3,4-tetrazol-5-yl)pyridin-3-yl]sulfonylamino]methyl]borinic acid, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: inhibitor, beta-lactamase, batsi, adc-7, antimicrobial protein, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Acinetobacter baumannii
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 164785.11

構造登録者

Powers, R.A.,Wallar, B.J. (登録日: 2017-06-26, 公開日: 2017-12-06, 最終更新日: 2023-10-04)

• 主引用文献: Bouza, A.A.,Swanson, H.C.,Smolen, K.A.,VanDine, A.L.,Taracila, M.A.,Romagnoli, C.,Caselli, E.,Prati, F.,Bonomo, R.A.,Powers, R.A.,Wallar, B.J.; Structure-Based Analysis of Boronic Acids as Inhibitors of Acinetobacter-Derived Cephalosporinase-7, a Unique Class C beta-Lactamase.; ACS Infect Dis, 4:325-336, 2018; PubMed: 29144724; DOI: 10.1021/acsinfecdis.7b00152

実験手法

X-RAY DIFFRACTION (2.09 Å)