5W8V
HUMAN HGPRT in complex with [(2-[(guanin-9-yl)methyl]propane-1,3-diyl)bis(oxy)]bis(methylene)diphosphonic acid
5W8V の概要
エントリーDOI | 10.2210/pdb5w8v/pdb |
分子名称 | Hypoxanthine-guanine phosphoribosyltransferase, {[(2R)-2-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-3-(2-phosphonoethoxy)propoxy]methyl}phosphonic acid, MAGNESIUM ION, ... (4 entities in total) |
機能のキーワード | 6-oxopurine; phosphoribosyltransferase; hypoxanthine; guanine; nucleoside phosphonate, transferase |
由来する生物種 | Homo sapiens (Human) |
細胞内の位置 | Cytoplasm: P00492 |
タンパク質・核酸の鎖数 | 4 |
化学式量合計 | 98753.98 |
構造登録者 | |
主引用文献 | Spacek, P.,Keough, D.T.,Chavchich, M.,Dracinsky, M.,Janeba, Z.,Naesens, L.,Edstein, M.D.,Guddat, L.W.,Hockova, D. Synthesis and Evaluation of Asymmetric Acyclic Nucleoside Bisphosphonates as Inhibitors of Plasmodium falciparum and Human Hypoxanthine-Guanine-(Xanthine) Phosphoribosyltransferase. J. Med. Chem., 60:7539-7554, 2017 Cited by PubMed: 28813147DOI: 10.1021/acs.jmedchem.7b00926 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.346 Å) |
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