5W5V

TBK1 co-crystal structure with amlexanox

Summary for 5W5V

• Entry DOI: 10.2210/pdb5w5v/pdb
• Descriptor: Serine/threonine-protein kinase TBK1, 2-amino-7-(1-methylethyl)-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid (2 entities in total)
• Functional Keywords: tbk1, kinase, amlexanox, obesity, diabetes, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 76324.22

Authors

Beyett, T.S.,Tesmer, J.J.G. (deposition date: 2017-06-15, release date: 2018-06-27, Last modification date: 2023-10-04)

• Primary citation: Beyett, T.S.,Gan, X.,Reilly, S.M.,Chang, L.,Gomez, A.V.,Saltiel, A.R.,Showalter, H.D.,Tesmer, J.J.G.; Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilonand Reveal Mechanisms for Selective Inhibition.; Mol. Pharmacol., 94:1210-1219, 2018; PubMed: 30082428; DOI: 10.1124/mol.118.112185

Experimental method

X-RAY DIFFRACTION (3.645 Å)