5VWM

Crystal structure of UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) from Pseudomonas aeruginosa in complex with CHIR-090 inhibitor

5VWM の概要

• エントリーDOI: 10.2210/pdb5vwm/pdb
• 分子名称: UDP-3-O-acyl-N-acetylglucosamine deacetylase, N-{(1S,2R)-2-hydroxy-1-[(hydroxyamino)carbonyl]propyl}-4-{[4-(morpholin-4-ylmethyl)phenyl]ethynyl}benzamide, ZINC ION, ... (7 entities in total)
• 機能のキーワード: inhibitor, seattle structural genomics center for infectious disease, ssgcid, lpxc, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 45461.26

構造登録者

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (登録日: 2017-05-22, 公開日: 2017-06-07, 最終更新日: 2023-10-04)

• 主引用文献: Delker, S.L.,Mayclin, S.J.,Phan, J.N.,Abendroth, J.,Lorimer, D.,Edwards, T.E.; Crystal structure of UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase (LpxC) from Pseudomonas aeruginosa in complex with CHIR-090 inhibitor; to be published,

実験手法

X-RAY DIFFRACTION (1.8 Å)