5VV6

Structure of bovine endothelial nitric oxide synthase heme domain in complex with 7-(((4-(Dimethylamino)phenethyl)amino)methyl)quinolin-2-amine

5VV6 の概要

• エントリーDOI: 10.2210/pdb5vv6/pdb
• 分子名称: Nitric oxide synthase, endothelial, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (9 entities in total)
• 機能のキーワード: nitric oxide synthase, inhibitor complex, heme enzyme, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Bos taurus (Bovine)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 102374.26

構造登録者

Li, H.,Poulos, T.L. (登録日: 2017-05-19, 公開日: 2017-08-16, 最終更新日: 2019-12-25)

• 主引用文献: Pensa, A.V.,Cinelli, M.A.,Li, H.,Chreifi, G.,Mukherjee, P.,Roman, L.J.,Martasek, P.,Poulos, T.L.,Silverman, R.B.; Hydrophilic, Potent, and Selective 7-Substituted 2-Aminoquinolines as Improved Human Neuronal Nitric Oxide Synthase Inhibitors.; J. Med. Chem., 60:7146-7165, 2017; PubMed: 28776992; DOI: 10.1021/acs.jmedchem.7b00835

実験手法

X-RAY DIFFRACTION (2 Å)