5VP2

Crystal structure of the Thermus thermophilus 70S ribosome in complex with madumycin II and bound to mRNA and A-, P- and E-site tRNAs at 2.8A resolution

This is a non-PDB format compatible entry.

Summary for 5VP2

• Entry DOI: 10.2210/pdb5vp2/pdb
• Descriptor: 23S Ribosomal RNA, 50S ribosomal protein L14, 50S ribosomal protein L15, ... (61 entities in total)
• Functional Keywords: madumycin ii, streptogramin a, antibiotic, ribosome inhibitor, 70s ribosome, ribosome structure, inhibition of translation, peptidyl transferase center, ribosome
• Biological source: Escherichia coli; More
• Total number of polymer chains: 112
• Total formula weight: 4571576.15

Authors

Osterman, I.A.,Khabibullina, N.F.,Komarova, E.S.,Kasatsky, P.,Kartsev, V.G.,Bogdanov, A.A.,Dontsova, O.A.,Konevega, A.L.,Sergiev, P.V.,Polikanov, Y.S. (deposition date: 2017-05-04, release date: 2017-06-28, Last modification date: 2024-04-24)

• Primary citation: Osterman, I.A.,Khabibullina, N.F.,Komarova, E.S.,Kasatsky, P.,Kartsev, V.G.,Bogdanov, A.A.,Dontsova, O.A.,Konevega, A.L.,Sergiev, P.V.,Polikanov, Y.S.; Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state.; Nucleic Acids Res., 45:7507-7514, 2017; PubMed: 28505372; DOI: 10.1093/nar/gkx413

Experimental method

X-RAY DIFFRACTION (2.8 Å)