5VMC

Influenza hemagglutinin H1 mutant DH1 in complex with 6'SLN

5VMC の概要

• エントリーDOI: 10.2210/pdb5vmc/pdb
• 関連するPDBエントリー: 5VMF 5VMG 5VMJ
• 関連するBIRD辞書のPRD_ID: PRD_900046
• 分子名称: Hemagglutinin HA1, Hemagglutinin HA2, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: influenza, hemagglutinin, receptor, viral protein
• 由来する生物種: Influenza A virus (strain A/Brevig Mission/1/1918 H1N1); 詳細
• 細胞内の位置: Virion membrane ; Single-pass type I membrane protein : Q9WFX3 Q9WFX3
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 177026.61

構造登録者

Ni, F.,Kondrashkina, E.,Wang, Q. (登録日: 2017-04-27, 公開日: 2017-11-08, 最終更新日: 2024-10-09)

主引用文献

Ni, F.,Kondrashkina, E.,Wang, Q.
Determinant of receptor-preference switch in influenza hemagglutinin.
Virology, 513:98-107, 2017

PubMed Abstract: Influenza pandemic occurs when a new strain from other animal species overcomes the inter-species barriers and supports rapid human-to-human transmission. A critical prerequisite to this process is that hemagglutinin (HA) acquires a few key mutations to switch from avian receptors to human receptors. Previous studies suggest that H1 and H2/H3 HAs use different sets of mutations for the switch. This report shows that HA from the 1918 H1N1 pandemic virus (1918H1 HA) adopts the set of mutations used by H2/H3 HAs in receptor-preference switch when its 130-loop is made similar to those of H2/H3 HAs. Thus, the 130-loop appears to be the key determinant for the different mutations employed by pandemic H1 or H2/H3 HA. The correlation of the mutational routes and the 130-loop as unraveled in this study opens the door for efficient investigation of mutations required by other HA subtypes for inter-human airborne transmission.

PubMed: 29055255
DOI: 10.1016/j.virol.2017.10.010

実験手法

X-RAY DIFFRACTION (2.15 Å)