5VDA

Crystal structure of human WEE1 kinase domain in complex with RAC-IV-101, a MK1775 analogue

5VDA の概要

• エントリーDOI: 10.2210/pdb5vda/pdb
• 関連するPDBエントリー: 5VC3 5VC4 5VC5 5VC6 5VD2 5VD4 5VD5 5VD7 5VD8
• 分子名称: Wee1-like protein kinase, 1-{6-[(1S)-1-hydroxyethyl]pyridin-2-yl}-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: kinase domain, cell cycle, wee1, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 33024.99

構造登録者

Zhu, J.-Y.,Schonbrunn, E. (登録日: 2017-04-01, 公開日: 2018-04-04, 最終更新日: 2024-03-06)

• 主引用文献: Zhu, J.-Y.,Schonbrunn, E.; Structural basis of Wee family kinase inhibition by small molecules; to be published,

実験手法

X-RAY DIFFRACTION (2.1 Å)