5V8L

BG505 SOSIP.664 trimer in complex with broadly neutralizing HIV antibodies 3BNC117 and PGT145

5V8L の概要

• エントリーDOI: 10.2210/pdb5v8l/pdb
• EMDBエントリー: 8643
• 分子名称: gp120, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (14 entities in total)
• 機能のキーワード: hiv, broadly neutralizing antibody, pgt145, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human immunodeficiency virus 1 (HIV-1); 詳細
• タンパク質・核酸の鎖数: 14
• 化学式量合計: 440359.20

構造登録者

Lee, J.H.,Ward, A.B. (登録日: 2017-03-22, 公開日: 2017-05-03, 最終更新日: 2020-07-29)

• 主引用文献: Lee, J.H.,Andrabi, R.,Su, C.Y.,Yasmeen, A.,Julien, J.P.,Kong, L.,Wu, N.C.,McBride, R.,Sok, D.,Pauthner, M.,Cottrell, C.A.,Nieusma, T.,Blattner, C.,Paulson, J.C.,Klasse, P.J.,Wilson, I.A.,Burton, D.R.,Ward, A.B.; A Broadly Neutralizing Antibody Targets the Dynamic HIV Envelope Trimer Apex via a Long, Rigidified, and Anionic beta-Hairpin Structure.; Immunity, 46:690-702, 2017; PubMed: 28423342; DOI: 10.1016/j.immuni.2017.03.017

実験手法

ELECTRON MICROSCOPY (4.3 Å)