5V74
Structure of the intact Haliangium ochraceum microcompartment shell
This is a non-PDB format compatible entry.
Summary for 5V74
| Entry DOI | 10.2210/pdb5v74/pdb |
| Descriptor | Ethanolamine utilization protein EutN/carboxysome structural protein Ccml, Microcompartments protein (3 entities in total) |
| Functional Keywords | bacterial microcompartments, structural protein |
| Biological source | Haliangium ochraceum (strain DSM 14365 / JCM 11303 / SMP-2) More |
| Total number of polymer chains | 270 |
| Total formula weight | 3493047.03 |
| Authors | Sutter, M.,Kerfeld, C.A. (deposition date: 2017-03-17, release date: 2017-06-21, Last modification date: 2024-04-03) |
| Primary citation | Sutter, M.,Greber, B.,Aussignargues, C.,Kerfeld, C.A. Assembly principles and structure of a 6.5-MDa bacterial microcompartment shell. Science, 356:1293-1297, 2017 Cited by PubMed Abstract: Many bacteria contain primitive organelles composed entirely of protein. These bacterial microcompartments share a common architecture of an enzymatic core encapsulated in a selectively permeable protein shell; prominent examples include the carboxysome for CO fixation and catabolic microcompartments found in many pathogenic microbes. The shell sequesters enzymatic reactions from the cytosol, analogous to the lipid-based membrane of eukaryotic organelles. Despite available structural information for single building blocks, the principles of shell assembly have remained elusive. We present the crystal structure of an intact shell from , revealing the basic principles of bacterial microcompartment shell construction. Given the conservation among shell proteins of all bacterial microcompartments, these principles apply to functionally diverse organelles and can inform the design and engineering of shells with new functionalities. PubMed: 28642439DOI: 10.1126/science.aan3289 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.51015467477 Å) |
Structure validation
Download full validation report
