5V5Y

CRYSTAL STRUCTURE OF HUMAN WEE1 KINASE DOMAIN IN COMPLEX WITH MK1775

Summary for 5V5Y

Entry DOI	10.2210/pdb5v5y/pdb
Descriptor	Wee1-like protein kinase, 1-[6-(2-hydroxypropan-2-yl)pyridin-2-yl]-6-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-2-(prop-2-en-1-yl)-1,2-dihydro-3H-pyrazolo[3,4-d]pyrimidin-3-one, DIMETHYL SULFOXIDE, ... (5 entities in total)
Functional Keywords	kinase domain, cell cycle, wee family, transferase, inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33221.90
Authors	ZHU, J.-Y.,SCHONBRUNN, E. (deposition date: 2017-03-15, release date: 2017-08-23, Last modification date: 2023-10-04)
Primary citation	Zhu, J.Y.,Cuellar, R.A.,Berndt, N.,Lee, H.E.,Olesen, S.H.,Martin, M.P.,Jensen, J.T.,Georg, G.I.,Schonbrunn, E. Structural Basis of Wee Kinases Functionality and Inactivation by Diverse Small Molecule Inhibitors. J. Med. Chem., 60:7863-7875, 2017 Cited by PubMed: 28792760 DOI: 10.1021/acs.jmedchem.7b00996 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation