5V43

Engineered human IgG Fc domain aglyco801

Summary for 5V43

Entry DOI	10.2210/pdb5v43/pdb
Descriptor	Ig gamma-1 chain C region (2 entities in total)
Functional Keywords	antibody engineering, fc fragment, immune system
Biological source	Homo sapiens (Human)
Cellular location	Secreted : P01857
Total number of polymer chains	2
Total formula weight	50985.66
Authors	Yan, W.,Marshall, N.,Zhang, Y.J. (deposition date: 2017-03-08, release date: 2017-06-21, Last modification date: 2017-09-27)
Primary citation	Lee, C.H.,Romain, G.,Yan, W.,Watanabe, M.,Charab, W.,Todorova, B.,Lee, J.,Triplett, K.,Donkor, M.,Lungu, O.I.,Lux, A.,Marshall, N.,Lindorfer, M.A.,Goff, O.R.,Balbino, B.,Kang, T.H.,Tanno, H.,Delidakis, G.,Alford, C.,Taylor, R.P.,Nimmerjahn, F.,Varadarajan, N.,Bruhns, P.,Zhang, Y.J.,Georgiou, G. IgG Fc domains that bind C1q but not effector Fc gamma receptors delineate the importance of complement-mediated effector functions. Nat. Immunol., 18:889-898, 2017 Cited by PubMed: 28604720 DOI: 10.1038/ni.3770 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.32 Å)

Structure validation