5UT5
JAK2 JH2 in complex with GLPG0634
Summary for 5UT5
| Entry DOI | 10.2210/pdb5ut5/pdb |
| Related | 5USY 5USZ 5UT0 5UT1 5UT2 5UT3 5UT4 5UT6 |
| Descriptor | Tyrosine-protein kinase JAK2, GLYCEROL, N-(5-{4-[(1,1-dioxidothiomorpholin-4-yl)methyl]phenyl}[1,2,4]triazolo[1,5-a]pyridin-2-yl)cyclopropanecarboxamide, ... (6 entities in total) |
| Functional Keywords | pseudokinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 34052.02 |
| Authors | Puleo, D.E.,Schlessinger, J. (deposition date: 2017-02-14, release date: 2017-06-07, Last modification date: 2023-10-04) |
| Primary citation | Newton, A.S.,Deiana, L.,Puleo, D.E.,Cisneros, J.A.,Cutrona, K.J.,Schlessinger, J.,Jorgensen, W.L. JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules. ACS Med Chem Lett, 8:614-617, 2017 Cited by PubMed: 28626520DOI: 10.1021/acsmedchemlett.7b00154 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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