5UT3
JAK2 JH2 in complex with IKK-2 Inhibitor VI
Summary for 5UT3
Entry DOI | 10.2210/pdb5ut3/pdb |
Descriptor | Tyrosine-protein kinase JAK2, 5-PHENYL-2-UREIDOTHIOPHENE-3-CARBOXAMIDE, GLYCEROL, ... (5 entities in total) |
Functional Keywords | pseudokinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 33717.59 |
Authors | Puleo, D.E.,Schlessinger, J. (deposition date: 2017-02-14, release date: 2017-06-07, Last modification date: 2023-10-04) |
Primary citation | Puleo, D.E.,Kucera, K.,Hammaren, H.M.,Ungureanu, D.,Newton, A.S.,Silvennoinen, O.,Jorgensen, W.L.,Schlessinger, J. Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders. ACS Med Chem Lett, 8:618-621, 2017 Cited by PubMed: 28626521DOI: 10.1021/acsmedchemlett.7b00153 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.501 Å) |
Structure validation
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