5USZ

JAK2 JH2 in complex with JNJ-7706621

Summary for 5USZ

• Entry DOI: 10.2210/pdb5usz/pdb
• Related: 5UT1 5UT2 5UT3 5UT4 5UT5 5UT6
• Descriptor: Tyrosine-protein kinase JAK2, 4-({5-amino-1-[(2,6-difluorophenyl)carbonyl]-1H-1,2,4-triazol-3-yl}amino)benzenesulfonamide, GLYCEROL, ... (5 entities in total)
• Functional Keywords: pseudokinase domain, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 33777.64

Authors

Puleo, D.E.,Schlessinger, J. (deposition date: 2017-02-14, release date: 2017-06-07, Last modification date: 2023-10-04)

• Primary citation: Puleo, D.E.,Kucera, K.,Hammaren, H.M.,Ungureanu, D.,Newton, A.S.,Silvennoinen, O.,Jorgensen, W.L.,Schlessinger, J.; Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders.; ACS Med Chem Lett, 8:618-621, 2017; PubMed: 28626521; DOI: 10.1021/acsmedchemlett.7b00153

Experimental method

X-RAY DIFFRACTION (2.103 Å)