5USX
Crystal structure of thioredoxin-disulfide reductase from Vibrio vulnificus CMCP6 in complex with NADP and FAD
Summary for 5USX
Entry DOI | 10.2210/pdb5usx/pdb |
Descriptor | Thioredoxin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total) |
Functional Keywords | structural genomics, center for structural genomics of infectious diseases, csgid, thioredoxin-disulfide reductase, oxidoreductase |
Biological source | Vibrio vulnificus CMCP6 |
Total number of polymer chains | 2 |
Total formula weight | 71947.37 |
Authors | Chang, C.,Grimshaw, S.,Maltseva, N.,Mulligan, R.,Anderson, W.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2017-02-14, release date: 2017-02-22, Last modification date: 2025-06-18) |
Primary citation | Inniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F. Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria. Microbiol Resour Announc, :e0020025-e0020025, 2025 Cited by PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications. PubMed: 40391899DOI: 10.1128/mra.00200-25 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.603 Å) |
Structure validation
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