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5USX

Crystal structure of thioredoxin-disulfide reductase from Vibrio vulnificus CMCP6 in complex with NADP and FAD

Summary for 5USX
Entry DOI10.2210/pdb5usx/pdb
DescriptorThioredoxin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, ... (5 entities in total)
Functional Keywordsstructural genomics, center for structural genomics of infectious diseases, csgid, thioredoxin-disulfide reductase, oxidoreductase
Biological sourceVibrio vulnificus CMCP6
Total number of polymer chains2
Total formula weight71947.37
Authors
Chang, C.,Grimshaw, S.,Maltseva, N.,Mulligan, R.,Anderson, W.F.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2017-02-14, release date: 2017-02-22, Last modification date: 2025-06-18)
Primary citationInniss, N.L.,Minasov, G.,Chang, C.,Tan, K.,Kim, Y.,Maltseva, N.,Stogios, P.,Filippova, E.,Michalska, K.,Osipiuk, J.,Jaroszewki, L.,Godzik, A.,Savchenko, A.,Joachimiak, A.,Anderson, W.F.,Satchell, K.J.F.
Structural genomics of bacterial drug targets: Application of a high-throughput pipeline to solve 58 protein structures from pathogenic and related bacteria.
Microbiol Resour Announc, :e0020025-e0020025, 2025
Cited by
PubMed Abstract: Antibiotic resistance remains a leading cause of severe infections worldwide. Small changes in protein sequence can impact antibiotic efficacy. Here, we report deposition of 58 X-ray crystal structures of bacterial proteins that are known targets for antibiotics, which expands knowledge of structural variation to support future antibiotic discovery or modifications.
PubMed: 40391899
DOI: 10.1128/mra.00200-25
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.603 Å)
Structure validation

239803

数据于2025-08-06公开中

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