5UQX
USP7 in complex with GNE6776 (6'-amino-4'-ethyl-5'-(4-hydroxyphenyl)-N-methyl-[3,3'-bipyridine]-6-carboxamide)
Summary for 5UQX
Entry DOI | 10.2210/pdb5uqx/pdb |
Related | 5UQV |
Descriptor | Ubiquitin carboxyl-terminal hydrolase 7, 6'-amino-4'-ethyl-5'-(4-hydroxyphenyl)-N-methyl[3,3'-bipyridine]-6-carboxamide (3 entities in total) |
Functional Keywords | hausp, usp7, sbdd, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Nucleus : Q93009 |
Total number of polymer chains | 2 |
Total formula weight | 85965.09 |
Authors | Murray, J.M.,Rouge, L. (deposition date: 2017-02-08, release date: 2017-10-25, Last modification date: 2023-10-04) |
Primary citation | Kategaya, L.,Di Lello, P.,Rouge, L.,Pastor, R.,Clark, K.R.,Drummond, J.,Kleinheinz, T.,Lin, E.,Upton, J.P.,Prakash, S.,Heideker, J.,McCleland, M.,Ritorto, M.S.,Alessi, D.R.,Trost, M.,Bainbridge, T.W.,Kwok, M.C.M.,Ma, T.P.,Stiffler, Z.,Brasher, B.,Tang, Y.,Jaishankar, P.,Hearn, B.R.,Renslo, A.R.,Arkin, M.R.,Cohen, F.,Yu, K.,Peale, F.,Gnad, F.,Chang, M.T.,Klijn, C.,Blackwood, E.,Martin, S.E.,Forrest, W.F.,Ernst, J.A.,Ndubaku, C.,Wang, X.,Beresini, M.H.,Tsui, V.,Schwerdtfeger, C.,Blake, R.A.,Murray, J.,Maurer, T.,Wertz, I.E. USP7 small-molecule inhibitors interfere with ubiquitin binding. Nature, 550:534-538, 2017 Cited by PubMed: 29045385DOI: 10.1038/nature24006 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.23 Å) |
Structure validation
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