5UOR
Structure-Based Design of ASK1 Inhibitors as Potential First-in-Class Agents for Heart Failure
Summary for 5UOR
Entry DOI | 10.2210/pdb5uor/pdb |
Related | 5UOX 5UP3 |
Descriptor | Mitogen-activated protein kinase kinase kinase 5, SULFATE ION, 6-{[(2S)-4-methylmorpholin-2-yl]methoxy}-2-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}-2,3-dihydro-1H-isoindol-1-one, ... (4 entities in total) |
Functional Keywords | transferase, metal-binding, apoptosis, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q99683 |
Total number of polymer chains | 2 |
Total formula weight | 61910.70 |
Authors | Dougan, D.R. (deposition date: 2017-02-01, release date: 2017-06-07, Last modification date: 2024-03-06) |
Primary citation | Lanier, M.,Pickens, J.,Bigi, S.V.,Bradshaw-Pierce, E.L.,Chambers, A.,Cheruvallath, Z.S.,Cole, D.,Dougan, D.R.,Ermolieff, J.,Gibson, T.,Halkowycz, P.,Hirokawa, A.,Ivetac, A.,Miura, J.,Nunez, E.,Sabat, M.,Tyhonas, J.,Wang, H.,Wang, X.,Swann, S. Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure. ACS Med Chem Lett, 8:316-320, 2017 Cited by PubMed: 28337323DOI: 10.1021/acsmedchemlett.6b00481 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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