5UOR

Structure-Based Design of ASK1 Inhibitors as Potential First-in-Class Agents for Heart Failure

5UOR の概要

• エントリーDOI: 10.2210/pdb5uor/pdb
• 関連するPDBエントリー: 5UOX 5UP3
• 分子名称: Mitogen-activated protein kinase kinase kinase 5, SULFATE ION, 6-{[(2S)-4-methylmorpholin-2-yl]methoxy}-2-{6-[4-(propan-2-yl)-4H-1,2,4-triazol-3-yl]pyridin-2-yl}-2,3-dihydro-1H-isoindol-1-one, ... (4 entities in total)
• 機能のキーワード: transferase, metal-binding, apoptosis, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm: Q99683
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61910.70

構造登録者

Dougan, D.R. (登録日: 2017-02-01, 公開日: 2017-06-07, 最終更新日: 2024-03-06)

• 主引用文献: Lanier, M.,Pickens, J.,Bigi, S.V.,Bradshaw-Pierce, E.L.,Chambers, A.,Cheruvallath, Z.S.,Cole, D.,Dougan, D.R.,Ermolieff, J.,Gibson, T.,Halkowycz, P.,Hirokawa, A.,Ivetac, A.,Miura, J.,Nunez, E.,Sabat, M.,Tyhonas, J.,Wang, H.,Wang, X.,Swann, S.; Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure.; ACS Med Chem Lett, 8:316-320, 2017; PubMed: 28337323; DOI: 10.1021/acsmedchemlett.6b00481

実験手法

X-RAY DIFFRACTION (2.75 Å)