5UOO
BRD4 bromodomain 2 in complex with CD161
Summary for 5UOO
| Entry DOI | 10.2210/pdb5uoo/pdb |
| Descriptor | Bromodomain-containing protein 4, 7-(3,5-dimethyl-1,2-oxazol-4-yl)-6-methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indole (3 entities in total) |
| Functional Keywords | bromodomain, transcription |
| Biological source | Homo sapiens (Human) |
| Cellular location | Nucleus: O60885 |
| Total number of polymer chains | 1 |
| Total formula weight | 15702.03 |
| Authors | Meagher, J.L.,Stuckey, J.A. (deposition date: 2017-02-01, release date: 2017-05-17, Last modification date: 2017-11-22) |
| Primary citation | Zhao, Y.,Bai, L.,Liu, L.,McEachern, D.,Stuckey, J.A.,Meagher, J.L.,Yang, C.Y.,Ran, X.,Zhou, B.,Hu, Y.,Li, X.,Wen, B.,Zhao, T.,Li, S.,Sun, D.,Wang, S. Structure-Based Discovery of 4-(6-Methoxy-2-methyl-4-(quinolin-4-yl)-9H-pyrimido[4,5-b]indol-7-yl)-3,5-dimethylisoxazole (CD161) as a Potent and Orally Bioavailable BET Bromodomain Inhibitor. J. Med. Chem., 60:3887-3901, 2017 Cited by PubMed: 28463487DOI: 10.1021/acs.jmedchem.7b00193 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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