5UNX

Structure of rat neuronal nitric oxide synthase heme domain in complex with 3-[(2-amino-4-methylquinolin-7-yl)methoxy]-5-(2-(methylamino)ethyl)benzonitrile

5UNX の概要

• エントリーDOI: 10.2210/pdb5unx/pdb
• 関連するPDBエントリー: 5UNR 5UNS 5UNT 5UNU 5UNV 5UNW 5UNY 5UNZ 5UO0 5UO1 5UO2 5UO3 5UO4 5UO5 5UO6 5UO7 5UO8 5UO9 5UOA 5UOB 5UOC 5UOD
• 分子名称: Nitric oxide synthase, brain, PROTOPORPHYRIN IX CONTAINING FE, 5,6,7,8-TETRAHYDROBIOPTERIN, ... (7 entities in total)
• 機能のキーワード: nitric, oxide, synthase, inhibitor, complex, heme, enzyme, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Rattus norvegicus (Rat)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 100216.87

構造登録者

Li, H.,Poulos, T.L. (登録日: 2017-01-31, 公開日: 2017-05-03, 最終更新日: 2023-10-04)

• 主引用文献: Cinelli, M.A.,Li, H.,Chreifi, G.,Poulos, T.L.,Silverman, R.B.; Nitrile in the Hole: Discovery of a Small Auxiliary Pocket in Neuronal Nitric Oxide Synthase Leading to the Development of Potent and Selective 2-Aminoquinoline Inhibitors.; J. Med. Chem., 60:3958-3978, 2017; PubMed: 28422508; DOI: 10.1021/acs.jmedchem.7b00259

実験手法

X-RAY DIFFRACTION (2.03 Å)