5ULN

Synthesis of novel seleno ureido containing compounds as SLC-0111 analogs. Investigations on carbonic anhydrases activity, glutathione peroxidase and X-ray crystallography

5ULN の概要

• エントリーDOI: 10.2210/pdb5uln/pdb
• 分子名称: Carbonic anhydrase 2, ZINC ION, GLYCEROL, ... (6 entities in total)
• 機能のキーワード: carbonic anhydrase inhibitors, metalloenzymes, glutathione peroxidase, lyase
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Cytoplasm : P00918
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 29817.93

構造登録者

Peat, T.S.,Angeli, A.,Tanini, D.,Bartolucci, G.,Capperucci, A.,Supuran, C.T.,Carta, F. (登録日: 2017-01-25, 公開日: 2017-10-11, 最終更新日: 2023-10-04)

• 主引用文献: Angeli, A.,Tanini, D.,Peat, T.S.,Di Cesare Mannelli, L.,Bartolucci, G.,Capperucci, A.,Ghelardini, C.,Supuran, C.T.,Carta, F.; Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.; ACS Med Chem Lett, 8:963-968, 2017; PubMed: 28947945; DOI: 10.1021/acsmedchemlett.7b00280

実験手法

X-RAY DIFFRACTION (1.35 Å)