5UJB

Structure of a Mcl-1 Inhibitor Binding to Site 3 of Human Serum Albumin

5UJB の概要

• エントリーDOI: 10.2210/pdb5ujb/pdb
• 分子名称: Serum albumin, 4-{8-chloro-11-[3-(4-chloro-3,5-dimethylphenoxy)propyl]-1-oxo-7-(1,3,5-trimethyl-1H-pyrazol-4-yl)-4,5-dihydro-1H-[1,4]diazepino[1,2-a]indol-2(3H)-yl}-1-methyl-1H-indole-6-carboxylic acid, PHOSPHATE ION (3 entities in total)
• 機能のキーワード: human serum albumin, free fraction, apoptosis, cancer, mcl-1, drug discovery, transport protein
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 140554.66

構造登録者

Zhao, B. (登録日: 2017-01-17, 公開日: 2017-05-03, 最終更新日: 2023-10-04)

• 主引用文献: Zhao, B.,Sensintaffar, J.,Bian, Z.,Belmar, J.,Lee, T.,Olejniczak, E.T.,Fesik, S.W.; Structure of a Myeloid cell leukemia-1 (Mcl-1) inhibitor bound to drug site 3 of Human Serum Albumin.; Bioorg. Med. Chem., 25:3087-3092, 2017; PubMed: 28428041; DOI: 10.1016/j.bmc.2017.03.060

実験手法

X-RAY DIFFRACTION (2.7 Å)