5UFX

Estrogen Receptor Alpha Ligand Binding Domain in Complex with OP1074

Summary for 5UFX

• Entry DOI: 10.2210/pdb5ufx/pdb
• Descriptor: Estrogen receptor, (2S)-3-(4-hydroxyphenyl)-4-methyl-2-(4-{2-[(3R)-3-methylpyrrolidin-1-yl]ethoxy}phenyl)-2H-1-benzopyran-7-ol (3 entities in total)
• Functional Keywords: breast cancer, estrogen, steroid, acquired resistance, transcription
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 57625.54

Authors

Fanning, S.W.,Hodges-Gallagher, L.,Myles, D.C.,Sun, R.,Fowler, C.E.,Green, B.D.,Harmon, C.L.,Greene, G.L.,Kushner, P.J. (deposition date: 2017-01-06, release date: 2018-01-10, Last modification date: 2023-10-04)

• Primary citation: Fanning, S.W.,Hodges-Gallagher, L.,Myles, D.C.,Sun, R.,Fowler, C.E.,Plant, I.N.,Green, B.D.,Harmon, C.L.,Greene, G.L.,Kushner, P.J.; Specific stereochemistry of OP-1074 disrupts estrogen receptor alpha helix 12 and confers pure antiestrogenic activity.; Nat Commun, 9:2368-2368, 2018; PubMed: 29915250; DOI: 10.1038/s41467-018-04413-3

Experimental method

X-RAY DIFFRACTION (1.5503 Å)