5U5C

Coiled Coil Peptide Metal Coordination Framework: Tetramer Fold

5U5C の概要

• エントリーDOI: 10.2210/pdb5u5c/pdb
• 関連するPDBエントリー: 5U59 5U5A 5U5B
• 分子名称: Designed tetrameric coiled coil peptide with one terpyridine side chain, COPPER (II) ION, HEXANE-1,6-DIOL, ... (4 entities in total)
• 機能のキーワード: designed peptide, synthetic, metal coordination framework, supramolecular assembly, de novo protein
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 20380.87

構造登録者

Tavenor, N.A.,Murnin, M.J.,Horne, W.S. (登録日: 2016-12-06, 公開日: 2017-02-22, 最終更新日: 2024-11-20)

主引用文献

Tavenor, N.A.,Murnin, M.J.,Horne, W.S.
Supramolecular Metal-Coordination Polymers, Nets, and Frameworks from Synthetic Coiled-Coil Peptides.
J. Am. Chem. Soc., 139:2212-2215, 2017

PubMed Abstract: Metal coordination and peptide-directed self-assembly are two proven methods for creating defined supramolecular architectures. Here, we report a new class of crystalline materials based on coiled-coil peptides bearing unnatural metal-chelating terpyridine moieties. High-resolution structural characterization of lattices formed in the presence of Cu reveals a general assembly mechanism. Subtle sequence variation in the modular synthetic ligand dictates assembly morphology.

PubMed: 28161945
DOI: 10.1021/jacs.7b00651

実験手法

X-RAY DIFFRACTION (2.1 Å)