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5U53

CTX-M-14 E166A with acylated ceftazidime molecule

Summary for 5U53
Entry DOI10.2210/pdb5u53/pdb
DescriptorBeta-lactamase, ACYLATED CEFTAZIDIME, NITRATE ION, ... (4 entities in total)
Functional Keywordsctx-m beta-lactamase, ceftazidime acyl-enzyme complex, hydrolase-antibiotic complex, hydrolase/antibiotic
Biological sourceEscherichia coli
Total number of polymer chains1
Total formula weight28580.06
Authors
Patel, M.,Stojanoski, V.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2016-12-06, release date: 2017-06-28, Last modification date: 2023-10-04)
Primary citationPatel, M.P.,Hu, L.,Stojanoski, V.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T.
The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M beta-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation.
Biochemistry, 56:3443-3453, 2017
Cited by
PubMed: 28613873
DOI: 10.1021/acs.biochem.7b00176
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.4 Å)
Structure validation

221051

數據於2024-06-12公開中

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