5U53
CTX-M-14 E166A with acylated ceftazidime molecule
Summary for 5U53
| Entry DOI | 10.2210/pdb5u53/pdb |
| Descriptor | Beta-lactamase, ACYLATED CEFTAZIDIME, NITRATE ION, ... (4 entities in total) |
| Functional Keywords | ctx-m beta-lactamase, ceftazidime acyl-enzyme complex, hydrolase-antibiotic complex, hydrolase/antibiotic |
| Biological source | Escherichia coli |
| Total number of polymer chains | 1 |
| Total formula weight | 28580.06 |
| Authors | Patel, M.,Stojanoski, V.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T. (deposition date: 2016-12-06, release date: 2017-06-28, Last modification date: 2023-10-04) |
| Primary citation | Patel, M.P.,Hu, L.,Stojanoski, V.,Sankaran, B.,Prasad, B.V.V.,Palzkill, T. The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M beta-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation. Biochemistry, 56:3443-3453, 2017 Cited by PubMed: 28613873DOI: 10.1021/acs.biochem.7b00176 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.4 Å) |
Structure validation
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