5U2N

Crystal structure of human NAMPT with A-1326133

5U2N の概要

関連するPDBエントリー5U2M
分子名称Nicotinamide phosphoribosyltransferase, SULFATE ION, N-{4-[1-(2-methylpropanoyl)piperidin-4-yl]phenyl}-2H-pyrrolo[3,4-c]pyridine-2-carboxamide, ... (4 entities in total)
機能のキーワードnampt inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
由来する生物種Homo sapiens (Human)
細胞内の位置Nucleus  P43490
ポリマー鎖数2
分子量合計109598.04
構造登録者
Longenecker, K.L.,Raich, D.,Korepanova, A.V. (登録日: 2016-11-30, 公開日: 2017-06-28, 最終更新日: 2018-03-21)
主引用文献
Wilsbacher, J.L.,Cheng, M.,Cheng, D.,Trammell, S.A.J.,Shi, Y.,Guo, J.,Koeniger, S.L.,Kovar, P.J.,He, Y.,Selvaraju, S.,Heyman, H.R.,Sorensen, B.K.,Clark, R.F.,Hansen, T.M.,Longenecker, K.L.,Raich, D.,Korepanova, A.V.,Cepa, S.,Towne, D.L.,Abraham, V.C.,Tang, H.,Richardson, P.L.,McLoughlin, S.M.,Badagnani, I.,Curtin, M.L.,Michaelides, M.R.,Maag, D.,Buchanan, F.G.,Chiang, G.G.,Gao, W.,Rosenberg, S.H.,Brenner, C.,Tse, C.
Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors.
Mol. Cancer Ther., 16:1236-1245, 2017
PubMed: 28468779 (主引用文献が同じPDBエントリー)
DOI: 10.1158/1535-7163.MCT-16-0819
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.73 Å)
?

構造検証レポート

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.19640.1%3.9%1.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード