5U1U

Crystal structure of the ATP-gated P2X7 ion channel bound to allosteric antagonist A740003

5U1U の概要

• エントリーDOI: 10.2210/pdb5u1u/pdb
• 関連するPDBエントリー: 5U1L 5U1V 5U1W 5U1X 5U1Y 5U2H
• 分子名称: P2X purinoceptor, 2-acetamido-2-deoxy-beta-D-glucopyranose, N-{(1R)-1-[N''-cyano-N'-(quinolin-5-yl)carbamimidamido]-2,2-dimethylpropyl}-2-(3,4-dimethoxyphenyl)acetamide (3 entities in total)
• 機能のキーワード: membrane protein: atp-gated ion channel: allosteric antagonist bound: closed state, membrane protein
• 由来する生物種: Ailuropoda melanoleuca (Giant panda)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 39854.41

構造登録者

Karasawa, A.,Kawate, T. (登録日: 2016-11-29, 公開日: 2017-01-11, 最終更新日: 2023-10-04)

• 主引用文献: Karasawa, A.,Kawate, T.; Structural basis for subtype-specific inhibition of the P2X7 receptor.; Elife, 5:-, 2016; PubMed: 27935479; DOI: 10.7554/eLife.22153

実験手法

X-RAY DIFFRACTION (3.604 Å)