5U12

E. coli dihydropteroate synthase complexed with an 8-mercaptoguanine derivative: 2-azanyl-8-[(2-fluorophenyl)methylsulfanyl]-1,9-dihydropurin-6-one

5U12 の概要

• エントリーDOI: 10.2210/pdb5u12/pdb
• 関連するPDBエントリー: 5U0V 5U0W 5U0X 5U0Y 5U0Z 5U10 5U11 5U13 5U14
• 分子名称: Dihydropteroate synthase, 2-azanyl-8-[(2-fluorophenyl)methylsulfanyl]-1,9-dihydropurin-6-one (3 entities in total)
• 機能のキーワード: e. coli, dhps, complex, pterin site, transferase
• 由来する生物種: Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62175.07

構造登録者

Dennis, M.L.,Peat, T.S.,Swarbrick, J.D. (登録日: 2016-11-27, 公開日: 2017-12-06, 最終更新日: 2023-10-04)

• 主引用文献: Dennis, M.L.,Lee, M.D.,Harjani, J.R.,Ahmed, M.,DeBono, A.J.,Pitcher, N.P.,Wang, Z.C.,Chhabra, S.,Barlow, N.,Rahmani, R.,Cleary, B.,Dolezal, O.,Hattarki, M.,Aurelio, L.,Shonberg, J.,Graham, B.,Peat, T.S.,Baell, J.B.,Swarbrick, J.D.; 8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.; Chemistry, 24:1922-1930, 2018; PubMed: 29171692; DOI: 10.1002/chem.201704730

実験手法

X-RAY DIFFRACTION (1.839 Å)