5TWO

Peroxisome proliferator-activated receptor gamma ligand binding domain in complex with a novel selectively PPAR gamma-modulating ligand VSP-51

Summary for 5TWO

Entry DOI	10.2210/pdb5two/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, PRO-SER-LEU-LEU-LYS-LYS-LEU-LEU-LEU-ALA-PRO, N-benzyl-1-[(4-chloro-3-fluorophenyl)methyl]-1H-indole-5-carboxamide, ... (4 entities in total)
Functional Keywords	peroxisome proliferator-activated receptor gamma, lignad binding domain, selective ppar gamma ligand, vsp-51, dna binding protein, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	33081.92
Authors	Yi, W.,Shi, J.,Zhao, G.,Zhou, X.E.,Suino-Powell, K.,Melcher, K.,Xu, H.E. (deposition date: 2016-11-14, release date: 2017-02-08, Last modification date: 2023-10-04)
Primary citation	Yi, W.,Shi, J.,Zhao, G.,Zhou, X.E.,Suino-Powell, K.,Melcher, K.,Xu, H.E. Identification of a novel selective PPAR gamma ligand with a unique binding mode and improved therapeutic profile in vitro. Sci Rep, 7:41487-41487, 2017 Cited by PubMed: 28128331 DOI: 10.1038/srep41487 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.927 Å)

Structure validation