5TWO

Peroxisome proliferator-activated receptor gamma ligand binding domain in complex with a novel selectively PPAR gamma-modulating ligand VSP-51

5TWO の概要

• エントリーDOI: 10.2210/pdb5two/pdb
• 分子名称: Peroxisome proliferator-activated receptor gamma, PRO-SER-LEU-LEU-LYS-LYS-LEU-LEU-LEU-ALA-PRO, N-benzyl-1-[(4-chloro-3-fluorophenyl)methyl]-1H-indole-5-carboxamide, ... (4 entities in total)
• 機能のキーワード: peroxisome proliferator-activated receptor gamma, lignad binding domain, selective ppar gamma ligand, vsp-51, dna binding protein, transcription
• 由来する生物種: Homo sapiens (Human); 詳細
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33081.92

構造登録者

Yi, W.,Shi, J.,Zhao, G.,Zhou, X.E.,Suino-Powell, K.,Melcher, K.,Xu, H.E. (登録日: 2016-11-14, 公開日: 2017-02-08, 最終更新日: 2023-10-04)

• 主引用文献: Yi, W.,Shi, J.,Zhao, G.,Zhou, X.E.,Suino-Powell, K.,Melcher, K.,Xu, H.E.; Identification of a novel selective PPAR gamma ligand with a unique binding mode and improved therapeutic profile in vitro.; Sci Rep, 7:41487-41487, 2017; PubMed: 28128331; DOI: 10.1038/srep41487

実験手法

X-RAY DIFFRACTION (1.927 Å)