5TOP

Atomic Resolution X-Ray Crystal Structure of a Ruthenocene Conjugated Beta-Lactam Antibiotic in Complex with CTX-M-14 S70G Beta-Lactamase

5TOP の概要

• エントリーDOI: 10.2210/pdb5top/pdb
• 分子名称: Beta-lactamase, POTASSIUM ION, [(1,2,3,4,5-eta)-1-(4-{[carboxy(4-carboxy-5,5-dimethyl-1,3-thiazolidin-2-yl)methyl]amino}-4-oxobutanoyl)cyclopentadienyl][(1,2,3,4,5-eta)-cyclopentadienyl]ruthenium, ... (7 entities in total)
• 機能のキーワード: beta-lactamase, organometallic, ruthenocene, ctx-m-14, hydrolase-antibiotic complex, hydrolase/antibiotic
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 58135.18

構造登録者

Lewandowski, E.M.,Chen, Y. (登録日: 2016-10-18, 公開日: 2017-11-08, 最終更新日: 2023-10-04)

• 主引用文献: Lewandowski, E.M.,Lethbridge, K.G.,Sanishvili, R.,Skiba, J.,Kowalski, K.,Chen, Y.; Mechanisms of proton relay and product release by Class A beta-lactamase at ultrahigh resolution.; FEBS J., 285:87-100, 2018; PubMed: 29095570; DOI: 10.1111/febs.14315

実験手法

X-RAY DIFFRACTION (1.18 Å)