5TOK

Crystal structure of the RSV F glycoprotein in complex with the neutralizing single-domain antibody F-VHH-L66

5TOK の概要

• エントリーDOI: 10.2210/pdb5tok/pdb
• 関連するPDBエントリー: 5TOJ
• 分子名称: Fusion glycoprotein F0, Fibritin chimera, Single-domain antibody F-VHH-L66, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• 機能のキーワード: fusion, nanobody, immunoglobulin fold, complex, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Human respiratory syncytial virus; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 226964.31

構造登録者

Gilman, M.S.A.,Kabeche, S.C.,McLellan, J.S. (登録日: 2016-10-17, 公開日: 2017-02-22, 最終更新日: 2023-10-04)

• 主引用文献: Rossey, I.,Gilman, M.S.,Kabeche, S.C.,Sedeyn, K.,Wrapp, D.,Kanekiyo, M.,Chen, M.,Mas, V.,Spitaels, J.,Melero, J.A.,Graham, B.S.,Schepens, B.,McLellan, J.S.,Saelens, X.; Potent single-domain antibodies that arrest respiratory syncytial virus fusion protein in its prefusion state.; Nat Commun, 8:14158-14158, 2017; PubMed: 28194013; DOI: 10.1038/ncomms14158

実験手法

X-RAY DIFFRACTION (3.8 Å)