5TN9

Crystal Structure of the ER-alpha Ligand-binding Domain (L372S,L536S) in Complex with the OBHS-BSC, 4-bromophenyl (1R,2R,4S)-5-(4-hydroxyphenyl)-6-(4-(2-(piperidin-1-yl)ethoxy)phenyl)-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate

5TN9 の概要

• エントリーDOI: 10.2210/pdb5tn9/pdb
• 関連するPDBエントリー: 5TNB
• 分子名称: Estrogen receptor, 4-bromophenyl (1S,2R,4S)-5-(4-hydroxyphenyl)-6-{4-[2-(piperidin-1-yl)ethoxy]phenyl}-7-oxabicyclo[2.2.1]hept-5-ene-2-sulfonate (3 entities in total)
• 機能のキーワード: nuclear receptor, transcription factor, ligand binding, protein-ligand complex, transcription
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Isoform 1: Nucleus . Isoform 3: Nucleus. Nucleus: P03372
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 119800.11

構造登録者

Nwachukwu, J.C.,Sharma, N.,Carlson, K.E.,Srinivasan, S.,Sharma, A.,Katzenellenbogen, J.A.,Nettles, K.W. (登録日: 2016-10-13, 公開日: 2017-02-15, 最終更新日: 2024-03-06)

• 主引用文献: Sharma, N.,Carlson, K.E.,Nwachukwu, J.C.,Srinivasan, S.,Sharma, A.,Nettles, K.W.,Katzenellenbogen, J.A.; Exploring the Structural Compliancy versus Specificity of the Estrogen Receptor Using Isomeric Three-Dimensional Ligands.; ACS Chem. Biol., 12:494-503, 2017; PubMed: 28032978; DOI: 10.1021/acschembio.6b00918

実験手法

X-RAY DIFFRACTION (2.253 Å)