5TKV

X-RAY CRYSTAL STRUCTURE OF THE "CLOSED" CONFORMATION OF CTP-INHIBITED E. COLI CYTIDINE TRIPHOSPHATE (CTP) SYNTHETASE

Summary for 5TKV

DescriptorCTP synthase, GLUTAMINE, SULFATE ION, ... (8 entities in total)
Functional Keywordspyrimidine biosynthesis, enzyme regulation via polymerization, feedback inhibition, lyase
Biological sourceEscherichia coli (strain K12)
Total number of polymer chains2
Total molecular weight127720.98
Authors
Baldwin, E.P.,Endrizzi, J.A. (deposition date: 2016-10-07, release date: 2017-04-26, Last modification date: 2017-11-01)
Primary citation
Lynch, E.M.,Hicks, D.R.,Shepherd, M.,Endrizzi, J.A.,Maker, A.,Hansen, J.M.,Barry, R.M.,Gitai, Z.,Baldwin, E.P.,Kollman, J.M.
Human CTP synthase filament structure reveals the active enzyme conformation.
Nat. Struct. Mol. Biol., 24:507-514, 2017
PubMed: 28459447 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.3407
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.7 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.20780.8%3.4%2.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution