5TKV
X-RAY CRYSTAL STRUCTURE OF THE "CLOSED" CONFORMATION OF CTP-INHIBITED E. COLI CYTIDINE TRIPHOSPHATE (CTP) SYNTHETASE
Summary for 5TKV
| Entry DOI | 10.2210/pdb5tkv/pdb |
| Descriptor | CTP synthase, GLUTAMINE, SULFATE ION, ... (8 entities in total) |
| Functional Keywords | pyrimidine biosynthesis, enzyme regulation via polymerization, feedback inhibition, lyase |
| Biological source | Escherichia coli (strain K12) |
| Total number of polymer chains | 2 |
| Total formula weight | 127720.98 |
| Authors | Baldwin, E.P.,Endrizzi, J.A. (deposition date: 2016-10-07, release date: 2017-04-26, Last modification date: 2023-10-04) |
| Primary citation | Lynch, E.M.,Hicks, D.R.,Shepherd, M.,Endrizzi, J.A.,Maker, A.,Hansen, J.M.,Barry, R.M.,Gitai, Z.,Baldwin, E.P.,Kollman, J.M. Human CTP synthase filament structure reveals the active enzyme conformation. Nat. Struct. Mol. Biol., 24:507-514, 2017 Cited by PubMed: 28459447DOI: 10.1038/nsmb.3407 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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