5TKV

X-RAY CRYSTAL STRUCTURE OF THE "CLOSED" CONFORMATION OF CTP-INHIBITED E. COLI CYTIDINE TRIPHOSPHATE (CTP) SYNTHETASE

5TKV の概要

• エントリーDOI: 10.2210/pdb5tkv/pdb
• 分子名称: CTP synthase, GLUTAMINE, SULFATE ION, ... (8 entities in total)
• 機能のキーワード: pyrimidine biosynthesis, enzyme regulation via polymerization, feedback inhibition, lyase
• 由来する生物種: Escherichia coli (strain K12)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 127720.98

構造登録者

Baldwin, E.P.,Endrizzi, J.A. (登録日: 2016-10-07, 公開日: 2017-04-26, 最終更新日: 2023-10-04)

• 主引用文献: Lynch, E.M.,Hicks, D.R.,Shepherd, M.,Endrizzi, J.A.,Maker, A.,Hansen, J.M.,Barry, R.M.,Gitai, Z.,Baldwin, E.P.,Kollman, J.M.; Human CTP synthase filament structure reveals the active enzyme conformation.; Nat. Struct. Mol. Biol., 24:507-514, 2017; PubMed: 28459447; DOI: 10.1038/nsmb.3407

実験手法

X-RAY DIFFRACTION (2.7 Å)